Physician Line Gry Larsen Department of Anaesthesiology, Odense University Hospital
Projektet i tal
OPEN undersøgelse/kliniske data
Forventet # af deltagere
Inkluderet antal deltagere
Inkluderede deltagere med prøver
Postoperative agitation in paediatric outpatiens - a randomized clinical trial with heart frequence variability and EEG monitoring
Postoperative agitation is a significant challenge in paediatric anaesthesia. This clinical trial aims to investigate if postoperative agitation in paediatric outpatients can be reduced when anaesthesia is guided by Narcotrend EEG monitor or mdoloris ANI monitor. We will include 90 patients and randomize to either standard treatment, anaeshtesia guided via ANI-monitoring or via EEG-monitoring.
Postoperative agitation is a significant challenge in paediatric anaesthesia, especially in preschool children. Current standard practice does not include neither EEG nor ANI monitoring. Postoperative agitation can be caused by pain and/or delirium and affects both child and surroundings. Thus, it is of relevance to examine if one of these two objective, non-invasive measures can reduce agitation when titrating anaesthesia levels to optimal sedation levels and anti-nociceptive levels. The Narcotrend monitor measures anaesthetic depth via an EEG. The ANI monitor measures nociception in the shape of heart rate variability.
We aim to examine if postoperative agitation in children can be reduces by applying one of these extra monitors. The primary outcome measure is RASS score, secondary outcomes are time consumption, use of analgesics and anaesthetics, pain, PONV and events.
Very few studies have examined and compared ANI with Narcotrend and, to the best of our knowledge, none in paediatrics.
Description of the cohort
Children aged 1-6 years (10-40 kg) ASA 1-2. No daily medicine (e.g. for asthmatics) planned for minor day surgery procedures in the Region of Southern Denmark
Data and biological material
The primary outcome measure will be RASS score. Secondary outcomes are time consumption, use of analgesics and anaesthetics, pain, PONV and events.
Collaborating researchers and departments
Department of Anaesthesiology, Odense University Hospital
MD, PhD, Pediatric Anaesthesiologist Tom G. Hansen
Doctor in specialist training, Sebastian Lé Greves
Doctor in specialist training, Marie Vegger
Med. Student Liv Erngaard
Department of Surgery and Intensive Care, Aabenraa Hospital