OPEN Research Support
head

Physician
Line Gry Larsen
Department of Anaesthesiology, Odense University Hospital


Projekt styring
Projekt status    Sampling ongoing
 
Data indsamlingsdatoer
Start 01.11.2018  
Slut 12.06.2020  
 



Postoperative agitation in paediatric outpatiens - a randomized clinical trial with heart frequence variability and EEG monitoring

Short summary

Postoperative agitation is a significant challenge in paediatric anaesthesia. This clinical trial aims to investigate if postoperative agitation in paediatric outpatients can be reduced when anaesthesia is guided by Narcotrend EEG monitor or mdoloris ANI monitor. We will include 90 patients and randomize to either standard treatment, anaeshtesia guided via ANI-monitoring or via EEG-monitoring.


Rationale

Postoperative agitation is a significant challenge in paediatric anaesthesia, especially in preschool children. Current standard practice does not include neither EEG nor ANI monitoring. Postoperative agitation can be caused by pain and/or delirium and affects both child and surroundings. Thus, it is of relevance to examine if one of these two objective, non-invasive measures can reduce agitation when titrating anaesthesia levels to optimal sedation levels and anti-nociceptive levels. The Narcotrend monitor measures anaesthetic depth via an EEG. The ANI monitor measures nociception in the shape of heart rate variability. We aim to examine if postoperative agitation in children can be reduces by applying one of these extra monitors. The primary outcome measure is RASS score, secondary outcomes are time consumption, use of analgesics and anaesthetics, pain, PONV and events. Very few studies have examined and compared ANI with Narcotrend and, to the best of our knowledge, none in paediatrics.


Description of the cohort

Children aged 1-6 years (10-40 kg) ASA 1-2. No daily medicine (e.g. for asthmatics) planned for minor day surgery procedures in the Region of Southern Denmark


Data and biological material

The primary outcome measure will be RASS score. Secondary outcomes are time consumption, use of analgesics and anaesthetics, pain, PONV and events.


Collaborating researchers and departments

Department of Anaesthesiology, Odense University Hospital

  • MD, PhD, Pediatric Anaesthesiologist Tom G. Hansen
  • Doctor in specialist training, Sebastian Lé Greves
  • Doctor in specialist training, Marie Vegger
  • Med. Student Liv Erngaard

Department of Surgery and Intensive Care, Aabenraa Hospital

  • Anaesthesiologist Carsten Thee