ICG-evaluation in necrotizing enterocolitis (NEC) patients
NEC is a dreaded disorder in preterm infants. A method for an objective evaluation is needed to prevent too excessive removal of intestine and leaving non-viable intestine. During surgery an ICG image will be obtained of the affected intestine. The images will be analyzed postoperative to estimate blood perfusion. Before closing a microdialysis catheter will be placed in the abdomen to collect samples of the peritoneal fluid, this fluid will be analyzed for the concentration of antibiotics.
This project aims to explore if new methods can improve the treatment of children with ischemic bowl disease.
1) The primary aim is to explore the use of Indocyanine green (ICG) to evaluate bowl perfusion with special emphasis on the delineation of the intestinal resections margins with special reference to the postoperative course.
2) The secondary aim is to investigate whether the diffusion of antibiotics into the peritoneal cavity is sufficient.
Description of the cohort
Infants with NEC at OUH requiring surgery
Data and biological material
Data consist of perotoniel microdialysis samples and video recordings of the bowl during the ICG- procedure
Collaborating researchers and departments
Department of Neonantology, H.C. Andersens børnehospital