Odense Chest Pain Biobank
Short Summary
In 2007, ESC and ACC announced a new definition of the existing MI-criteria from 2000. With this project we expect to contribute with significant information to the consequences of the 2007-criterias. This information will affect the science, the clinician as well as the patient.
Rationale
In 2007, ESC and ACC announced a new definition of the existing MI-criteria from 2000. The new guidelines maintain troponin as the preferred coronary marker and a discretionary limit of the 99 percentile of a reference population. The most notable difference from the 2007-definition is the implementation of five MI sub-types, where MI type 2 regards a whole new category of patients. With this group, distinction is made between MI caused by damage in the wall of the coronary (Type 1 MI) and type 2 MI, which is either activated by reduced oxygen to the heart or increased oxygen to the heart.
Description of the cohort
From January 6th 2010 until January 5th 2011 all patients, who have had their Troponin I level determined during their hospitalization at Odense University Hospital, have been asked for permission to draw an extra blood sample. The biobank which hereby is established now included 2.553 patients. Furthermore an examination including ECG and a thorough history of the patiens chest pain has taken place. Patients fulfilling the criterium for acute myocardial infarction (AMI) has been categorized as type 1-5 MI according to the international redifinition of MI from 2007. Patients who did not get the diagnosis AMI has been diagnosed by an end point commitee.
Data and biological material
The data from the biobank is used in two PhD-studies: Lotte Saabye (DEF-AMI) which describe the prevalence and the prognostic meaning of the 5 MI types. Susanne Hosbond (BIO-COR) which illustrates the activity of different biomarkers in the arterial wall in patients with ischemic heart disease.
Collaborating researchers and departments
| Department | Researcher(s) |
|---|---|
| Department of Cardiology and Cardiovascular, Odense University Hospital | PhD-student Lotte Saaby, PhD-student Susanne Hosbond, 1. registrar Tina Svenstrup Poulsen, PhD, Clinical Associated Professor and Senior Hospital Physician Axel Diederichsen, PhD, Associatede Professor and Senior Hospital Physician Hans Mickley, DMSc, Research Laboratory Technologist Lone Sørensen, Research Laboratory Technologist Maybritt Rønn, Medical Director Mogens Lytken Larsen |
| Department of Biochemistry and Pharmacology, Odense University Hospital | Professor Lars Melholt Rasmussen, Professor Jesper Hallas, Senior Hospital Physician Mads Nybo, PhD |
| Department of Nuclear Medicine, Odense University Hospital | Professor Poul Flemming Høilund Carlsen |
| OPEN Odense Patient data Explorative Network | Professor and Manager Torben Barington |
| Department of Health Science and Technology, Aalborg Hospital | Senior Hospital Physician Torben Bjerregård Larsen |
| Department of Clinical Medicine, Aarhus University Hospital | Professor and Chairman for the Global MI Task Force Kristian Thygesen |
| University of Arizona College of Medicine, Tucson, Arizona, USA | Professor of Medicine Joseph S. Alpert, MD, FACC, FAHA, FESC |
Publications associated with the project
Hvis du er interesseret i data eller biologisk materiale fra dette projekt, tag da kontakt til open@rsyd.dk, OPEN vil så kontakte den pågældende forsker for at høre om mulighederne for samarbejde. OPEN hjælper sundhedsvidenskabelige forskere i Region Syddanmark med dataindsamling, biobank, registerdata og formalia omkring deres forskningsprojekter.